PTPN22 MaxPab mouse polyclonal antibody (B01)
产品名称： PTPN22 MaxPab mouse polyclonal antibody (B01)
英文名称： PTPN22 MaxPab mouse polyclonal antibody (B01)
产品编号： H00026191-B01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human PTPN22 protein.
- Immunogen:
- PTPN22 (AAH71670.1, 1 a.a. ~ 752 a.a) full-length human protein.
- Sequence:
- MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGSQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNSSSFLNFGFANRFSKPKGPRNPPPTWNI
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- Note:
- For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
- MSDS:
Download
- Publication Reference
- 1.
- High Basal Activity of the PTPN22 Gain-of-Function Variant Blunts Leukocyte Responsiveness Negatively Affecting IL-10 Production in ANCA Vasculitis.
Cao Y, Yang J, Colby K, Hogan SL, Hu Y, Jennette CE, Berg EA, Zhang Y, Jennette JC, Falk RJ, Preston GA.PLoS One. 2012;7(8):e42783. Epub 2012 Aug 3.
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of PTPN22 expression in transfected 293T cell line (H00026191-T01) by PTPN22 MaxPab polyclonal antibody.
Lane1:PTPN22 transfected lysate(82.72 KDa).
Lane2:Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 26191
- GeneBank Accession#:
- BC071670.1
- Protein Accession#:
- AAH71670.1
- Gene Name:
- PTPN22
- Gene Alias:
- LYP,Lyp1,Lyp2,PEP,PTPN8
- Gene Description:
- protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000013720,lymphoid-specific protein tyrosine phosphatase,protein tyrosine phosphatase, non-receptor type 8
- Related Disease
- Acute Disease
- Addison Disease
- Alopecia Areata
- Anemia, Aplastic
- Arthritis
- Arthritis, Juvenile Rheumatoid
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Autoimmune Diseases
- Autoimmune polyglandular syndrome
- Bacterial Infections
- Behcet Syndrome
- Bipolar Disorder
- Brucellosis
- Carcinoma