FITC标记的钙激活氯离子通道蛋白3抗体
产品名称： FITC标记的钙激活氯离子通道蛋白3抗体
英文名称： Anti-CLCA3/FITC
产品编号： HZ-13706R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CLCA3/FITC Conjugated antibody
FITC标记的钙激活氯离子通道蛋白3抗体
| 英文名称 | Anti-CLCA3/FITC |
| 中文名称 | FITC标记的钙激活氯离子通道蛋白3抗体 |
| 别 名 | Calcium activated chloride channel 3; Calcium-activated chloride channel regulator family member 3; Chloride channel accessory 3 pseudogene; chloride channel calcium activated 3; Chloride channel calcium activated family member 3; Clca1; Clca2; CLCA3P; Gob 5; Gob-5; Gob5; hCLCA3; mCLCA3; MGC143984; MGC143985. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, Dog, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 98kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CLCA3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The calcium-activated chloride channel (CLCA) protein family, which includes the human homologs CLCA1 and CLCA2, display distinct tissue distribution patterns. CLCA1 is expressed as a precursor protein that is processed into two cell surface associated subunits and a group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the expression of mucins. CLCA1 may provide a therapeutic target to control mucus overproduction in airway disease patients with cystic fibrosis. CLCA2 expression is downregulated in breast cancer, therefore CLCA2 is thought to act as a tumor suppressor in normal cells. CLCA3 (known as Clca3 in mouse) is a structurally divergent member of the CLCA family that does not function as a channel protein. CLCA4 is a CLCA member that is expressed in human rectal mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is primarily expressed in intestine and stomach. Function: mCLCA3 (alias gob-5) is the third murine member of the family of calcium-activated chloride channels (CLCA-family). mCLCA3 plays a role in diseases with secretory dysfunctions, including asthma and cystic fibrosis. The mCLCA3 protein is located in mucin granule membranes of goblet cells of the intestinal, respiratory and reproductive tracts. It is also secreted into the mucin layer on mucosal membranes. The protein appears to be involved in the synthesis, condensation or secretion of mucins. Subcellular Location: Secreted Tissue Specificity: Exclusively expressed in the digestive and respiratory tracts and in the uterus (at protein level). Expressed in small intestine, colon, stomach, and uterus and slightly expressed in trachea tissue. Exclusively expressed in the mucin granule membranes of gastrointestinal, respiratory, and uterine goblet cells and other mucin-producing cells. In the colon, expressed in the surface mucous cells. In the stomach highly expressed in the surface epithelium in the pylorus. Strongly expressed in the airway epithelium of lung tissues associated with airway hyperresponsiveness (AHR). Post-translational modifications: he 110 kDa translation product is cleaved in the endoplasmic reticulum into a 75 kDa N-terminal and a 35 kDa C-terminal products that remain physically associated with each other. Glycosylated. Similarity: Belongs to the CLCR family. Contains 1 VWFA domain. Database links: Entrez Gene: 23844 Mouse SwissProt: Q8R049 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
钙激活氯通道（CLCA）蛋白家族包括人类同源物CLCA1和CLCA2，显示出不同的组织分布模式。CLCA1被表达为前体蛋白，其被加工成两个细胞表面相关亚基和一组蛋白质。CLCA1由白细胞介素-9上调，并调节粘蛋白的表达。CLACA1可能为控制囊性纤维化气道疾病患者黏液过度生成提供治疗靶点。CLCA2在乳腺癌中表达下调，因此认为CLCA2在正常细胞中起抑制肿瘤作用。CLCA3（在小鼠中称为Clca3）是CLCA家族中不具有通道蛋白功能的结构分化成员。CLCA4是在人直肠粘膜中表达的CLCA成员，CLCA5在眼和脾脏中表达较强，CLCA6主要在肠和胃中表达。