TNFSF11 MaxPab mouse polyclonal antibody (B01)
产品名称： TNFSF11 MaxPab mouse polyclonal antibody (B01)
英文名称： TNFSF11 MaxPab mouse polyclonal antibody (B01)
产品编号： H00008600-B01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human TNFSF11 protein.
- Immunogen:
- TNFSF11 (NP_143026, 1 a.a. ~ 244 a.a) full-length human protein.
- Sequence:
- MDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- Note:
- For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of TNFSF11 expression in transfected 293T cell line (H00008600-T01) by TNFSF11 MaxPab polyclonal antibody.
Lane 1: TNFSF11 transfected lysate(26.84 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 8600
- GeneBank Accession#:
- NM_033012
- Protein Accession#:
- NP_143026
- Gene Name:
- TNFSF11
- Gene Alias:
- CD254,ODF,OPGL,OPTB2,RANKL,TRANCE,hRANKL2,sOdf
- Gene Description:
- tumor necrosis factor (ligand) superfamily, member 11
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq
- Other Designations:
- OTTHUMP00000178585,TNF-related activation-induced cytokine,osteoclast differentiation factor,osteoprotegerin ligand,receptor activator of nuclear factor kappa B ligand,tumor necrosis factor ligand superfamily, member 11
- Gene Pathway
- Related Disease
- Acute Disease
- Alveolar Bone Loss
- Alzheimer Disease
- Alzheimer disease
- Arthritis, Rheumatoid
- Bone Diseases, Metabolic
- Bone Resorption
- Calcinosis
- Cardiovascular Diseases
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Fractures, Bone
- Fractures, Spontaneous
- Genetic Predisposition to Disease
- Lupus Erythematosus, Systemic
- Metabolic Syndrome X
- Neoplasms