FITC标记的RRP4蛋白抗体
产品名称： FITC标记的RRP4蛋白抗体
英文名称： Anti-RRP4/FITC
产品编号： HZ-18859R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RRP4/FITC Conjugated antibody
FITC标记的RRP4蛋白抗体
| 英文名称 | Anti-RRP4/FITC |
| 中文名称 | FITC标记的RRP4蛋白抗体 |
| 别 名 | EXOSC2; Exosome complex exonuclease RRP4; Exosome component 2; hRrp4p; OTTHUMP00000022370; OTTHUMP00000022371; OTTHUMP00000022372; OTTHUMP00000022373; OTTHUMP00000022374; p7; Ribosomal RNA processing protein 4; RRP4; Rrp4p. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Macaque Monkey, Rhesus monkey, Gorilla, Opossum, Marmoset (c |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRP4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Rrp4 and Ski7p are components of the cytoplasmic exosome complex, and together with the RNA helicase Ski2p they are necessary for degradation of deadenylated mRNA. Rrp4 is required for the 3’ to 5’ exonuclease activity that produces the 3’ end of the 5.8S rRNA. Rrp4 also functions as a subunit of the specialized trypanosome exosome complex. Function: The exosome, present in both the nucleus and cytoplasm of all eukaryotic cells, is a complex of 3'-5' exoribonucleases containing at least nine core components. Recently, it has been demonstrated, mainly by analyses in yeast, that the nuclear exosome is essential for rRNA processing and sn(o)RNA biogenesis. Furthermore, it is involved in the degradation of improperly processed mRNAs. The cytoplasmic exosome participates in normal mRNA turnover and in the degradation of inherently instable mRNAs that contain AU-rich elements. Therefore, the exosome plays a key role in RNA metabolism. Subcellular Location: Cytoplasmic, Exosome and Nuclear Similarity: Belongs to the RRP1 family. Database links: Entrez Gene: 615712 Cow Entrez Gene: 608606 Dog Entrez Gene: 101126796 Gorilla Entrez Gene: 23404 Human Entrez Gene: 100397822 Marmoset (common) Entrez Gene: 227715 Mouse Entrez Gene: 100439017 Orangutan Entrez Gene: 595050 Xenopus tropicalis GenBank: NP_055100.2 Human Omim: 602238 Human SwissProt: Q2KID0 Cow SwissProt: Q13868 Human SwissProt: Q8VBV3 Mouse Unigene: 654643 Huma Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Rrp4和Sky7p是细胞质外体复合物的组分，它们与RNA螺旋酶Ski2p一起是降解脱脱脱烯化mRNA所必需的。RRP4需要3’至5’核酸外切酶活性，产生5.8S rRNA的3′端。RRP4还作为特异性锥虫外体复合体的亚基。