CACNB4 polyclonal antibody
产品名称： CACNB4 polyclonal antibody
英文名称： CACNB4 polyclonal antibody
产品编号： PAB6720
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of CACNB4.
- Immunogen:
- A synthetic peptide corresponding to human CACNB4.
- Sequence:
- CSPGGYSHDSRHRL
- Host:
- Goat
- Theoretical MW (kDa):
- 54.7, 58.2, 56.4
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize all reported protein isoforms of human CACNB4 (NP_001005747.1, NP_000717.2, NP_001005746.1, ).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:8000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions.
Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA.Science. 2005 Jan 7;307(5706):117-21.
- Entrez GeneID:
- 785
- Protein Accession#:
- NP_001005747.1;NP_000717.2;NP_001005746.1
- Gene Name:
- CACNB4
- Gene Alias:
- CAB4,CACNLB4,EA5,EJM
- Gene Description:
- calcium channel, voltage-dependent, beta 4 subunit
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- dihydropyridine-sensitive L-type, calcium channel beta-4 subunit,voltage dependent calcium channel beta 4 subunit
- Related Disease